生态环境学报 ›› 2023, Vol. 32 ›› Issue (11): 2062-2071.DOI: 10.16258/j.cnki.1674-5906.2023.11.016
收稿日期:
2023-04-07
出版日期:
2023-11-18
发布日期:
2024-01-17
作者简介:
高晓宇(1992年生),女,博士研究生,研究方向为抗生素抗性基因的环境行为及阻控。E-mail: gxy1010gxy@tongji.edu.cn
基金资助:
Received:
2023-04-07
Online:
2023-11-18
Published:
2024-01-17
摘要:
细菌耐药性给人类健康及公共卫生带来巨大的威胁。土壤尤其是农业土壤是环境中抗生素抗性重要的源库。为减少抗生素抗性基因(ARGs)的传播风险,了解其在土壤中的传播规律非常重要。通过总结分析国内外发表的相关文献,对目前ARGs在土壤中的积累、转移情况及消减特征进行了综述。已有调查结果发现,农业发达及经济发地区土壤是ARGs积累的热区。有机肥施用及污水灌溉等原因导致ARGs在土壤中持续积累,其丰度可达102 gene copies/16S rRNA gene copies。胞内抗生素抗性基因(iARGs)、胞外游离抗生素抗性基因(eARGs)是ARGs的两种赋存形态,其中,iARGs是主要的赋存形态。iARGs通过接合转移、转导在土壤中传播,其中接合转移是目前研究最多及最主要的水平转移方式。eARGs通过转化在土壤中传播。胞外DNA可以在土壤中留存几个月甚至一年以上,由于检测方法的限制eARGs在土壤中的自然转化并不经常被发现,因此,对土壤eARGs的风险研究有所忽略。外源ARGs进入土壤后的命运受到ARGs种类、形态、土壤特性、污染物等因素的影响。ARB进入土壤后逐渐死亡及游离DNA逐渐降解的这一时间段是外源ARGs能否在土壤中传播的重要时间节点,很有可能成为控制ARGs在土壤中传播的关键节点。目前关于携带ARGs的宿主细菌进入土壤后的消减规律的研究还处于起步阶段,仍需开展深入的研究。针对土壤ARGs消减的强化措施主要包括改变农艺措施、施加生物炭、噬菌体疗法等,但效果不一且有限。在未来的研究中应对游离的eARGs产生的环境效应给予重视,加强对ARGs在土壤中传播的关键影响因子的研究并开发新的强化措施以加快ARGs的消减。
中图分类号:
高晓宇, 王磊. 抗生素抗性基因在土壤中积累、转移与消减的研究进展[J]. 生态环境学报, 2023, 32(11): 2062-2071.
GAO Xiaoyu, WANG Lei. The Accumulation, Transfer and Elimination of Antibiotic Resistance Genes in Soil: A Review[J]. Ecology and Environment, 2023, 32(11): 2062-2071.
地区 | 土壤利用类型 | ARGs来源 | ARGs | ARGs/16S rRNA | 参考文献 |
---|---|---|---|---|---|
山东 | 蔬菜大棚 | 有机肥 | tetW, tetM, tetO, tetT | 3.70×10−5-1.25×102 | Zhao et al., |
山东 | 蔬菜大棚 | 有机肥 | sul1, sul2 | 3.97×10−3-9.94×102 | Zhao et al., |
江西/湖南 | 水稻 | 有机肥 | tetA, tetG, tetM, tetO, tetQ, tetW | 2.43×10−7-2.44×10−3 | Tang et al., |
江西/湖南 | 水稻 | 有机肥 | sul1, sul2 | 2.28×10−5-5.95×10−3 | Tang et al., |
安徽 | 小麦/大豆轮作 | 牛粪/猪粪 | 38种ARGs | 9.86×10−6-1.38×10−1 | Peng et al., |
北京/天津/浙江 | ‒ | 猪粪 | tetM, tetO, tetQ, tetW | 6.68×10−8-2.41×10−2 | Wu et al., |
福建 | 农田/菜地 | 猪粪 | tetO, tetW, tetM, tetA, tetX | 1.01 ×10−6-1.70×10−2 | Huang et al., |
30省 | 农田 | ‒ | sul1, sul2 | 4.90×10−8-1.10×10−2 | Zhou et al., |
30省 | 农田 | ‒ | tetM, tetW, tetQ, tetO, tetT, tetB/P | 7.03×10−8-8.80×10−2 | Zhou et al., |
上海 | 农田 | 堆肥 | sul1, sul2 | 2.37×10−5-4.23×10−2 | Ji et al., |
‒ | 菜地 | 粪便 | sul1, sul2 | 10−4-10−3 | Wang et al., |
‒ | 菜地 | 粪便 | tetM, tetO, tetW, tetB/P | 10−5-10−3 | Wang et al., |
表1 中国不同地区粪肥施用土壤中ARGs的丰度
Table 1 Abundance of some selected ARGs in manure application soils from different regions of China
地区 | 土壤利用类型 | ARGs来源 | ARGs | ARGs/16S rRNA | 参考文献 |
---|---|---|---|---|---|
山东 | 蔬菜大棚 | 有机肥 | tetW, tetM, tetO, tetT | 3.70×10−5-1.25×102 | Zhao et al., |
山东 | 蔬菜大棚 | 有机肥 | sul1, sul2 | 3.97×10−3-9.94×102 | Zhao et al., |
江西/湖南 | 水稻 | 有机肥 | tetA, tetG, tetM, tetO, tetQ, tetW | 2.43×10−7-2.44×10−3 | Tang et al., |
江西/湖南 | 水稻 | 有机肥 | sul1, sul2 | 2.28×10−5-5.95×10−3 | Tang et al., |
安徽 | 小麦/大豆轮作 | 牛粪/猪粪 | 38种ARGs | 9.86×10−6-1.38×10−1 | Peng et al., |
北京/天津/浙江 | ‒ | 猪粪 | tetM, tetO, tetQ, tetW | 6.68×10−8-2.41×10−2 | Wu et al., |
福建 | 农田/菜地 | 猪粪 | tetO, tetW, tetM, tetA, tetX | 1.01 ×10−6-1.70×10−2 | Huang et al., |
30省 | 农田 | ‒ | sul1, sul2 | 4.90×10−8-1.10×10−2 | Zhou et al., |
30省 | 农田 | ‒ | tetM, tetW, tetQ, tetO, tetT, tetB/P | 7.03×10−8-8.80×10−2 | Zhou et al., |
上海 | 农田 | 堆肥 | sul1, sul2 | 2.37×10−5-4.23×10−2 | Ji et al., |
‒ | 菜地 | 粪便 | sul1, sul2 | 10−4-10−3 | Wang et al., |
‒ | 菜地 | 粪便 | tetM, tetO, tetW, tetB/P | 10−5-10−3 | Wang et al., |
[1] |
ARNOLD B J, HUANG I T, HANAGE W P, 2022. Horizontal gene transfer and adaptive evolution in bacteria[J]. Nature Reviews Microbiology, 20(4): 206-218.
DOI |
[2] |
BILLARD-POMARES T, FOUTEAU S, JACQUET M E, et al., 2014. Characterization of a P1-Like bacteriophage carrying an SHV-2 extended-spectrum -lactamase from an escherichia coli strain[J]. Antimicrobial Agents and Chemotherapy, 58(11): 6550-6557.
DOI URL |
[3] |
BLUM S A E, LORENZ M G, WACKERNAGEL W, 1997. Mechanism of retarded DNA degradation and prokaryotic origin of DNases in nonsterile soils[J]. Systematic and Applied Microbiology, 20(4): 513-521.
DOI URL |
[4] |
CALERO-CACERES W, YE M, BALCAZAR J L, 2019. Bacteriophages as environmental reservoirs of antibiotic resistance[J]. Trends in Microbiology, 27(7): 570-577.
DOI URL |
[5] |
CHEE-SANFORD J C, MACKIE R I, KOIKE S, et al., 2009. Fate and transport of antibiotic residues and antibiotic resistance genes following land application of manure waste[J]. Journal Of Environmental Quality, 38(3): 1086-1108.
DOI URL |
[6] |
CHEN C Q, LI J, CHEN P P, et al., 2014. Occurrence of antibiotics and antibiotic resistances in soils from wastewater irrigation areas in Beijing and Tianjin, China[J]. Environmental Pollution, 193: 94-101.
DOI PMID |
[7] |
CHEN Q L, FAN X T, ZHU D, et al., 2018. Effect of biochar amendment on the alleviation of antibiotic resistance in soil and phyllosphere of Brassica chinensis L.[J]. Soil Biology and Biochemistry, 119: 74-82.
DOI URL |
[8] |
CHEN Q L, HU H W, YAN Z Z, et al., 2022. Cross-biome antibiotic resistance decays after millions of years of soil development[J]. The ISME journal, 16(7): 1864-1867.
DOI URL |
[9] |
CHENG W X, LI J, WU Y, et al., 2016. Behavior of antibiotics and antibiotic resistance genes in eco-agricultural system: A case study[J]. Journal Of Hazardous Materials, 304: 18-25.
DOI PMID |
[10] |
CHO I, BLASER M J, 2012. The human microbiome: at the interface of health and disease[J]. Nature Reviews Genetics, 13(4): 260-270.
DOI PMID |
[11] |
COTTELL J L, WEBBER M A, PIDDOCK L J, 2012. Persistence of transferable extended-spectrum-beta-lactamase resistance in the absence of antibiotic pressure[J]. Antimicrob Agents Chemother, 56(9): 4703-4706.
DOI URL |
[12] |
CUI E P, GAO F, LIU Y, et al., 2018. Amendment soil with biochar to control antibiotic resistance genes under unconventional water resources irrigation: Proceed with caution[J]. Environmental Pollution, 240: 475-484.
DOI URL |
[13] |
DAVIES J, DAVIES D, 2010. Origins and evolution of antibiotic resistance[J]. Microbiology and Molecular Biology Reviews, 74(3): 417-433.
DOI PMID |
[14] |
DE VRIES J, WILFRIED W, 2004. Microbial horizontal gene transfer and the DNA release from transgenic crop plants[J]. Plant and Soil, 266(1): 91-104.
DOI URL |
[15] |
DONG P Y, WANG H, FANG T T, et al., 2019. Assessment of extracellular antibiotic resistance genes (eARGs) in typical environmental samples and the transforming ability of eARG[J]. Environment International, 125: 90-96.
DOI PMID |
[16] |
DUAN M L, LI H C, GU J, et al., 2017. Effects of biochar on reducing the abundance of oxytetracycline, antibiotic resistance genes, and human pathogenic bacteria in soil and lettuce[J]. Environmental Pollution, 224: 787-795.
DOI PMID |
[17] |
ENNIS C J, EVANS A G, ISLAM M, et al., 2012. Biochar: Carbon sequestration, land remediation, and impacts on soil microbiology[J]. Critical Reviews in Environmental Science and Technology, 42(22): 2311-2364.
DOI URL |
[18] |
FAN X T, LI H, CHEN Q L, et al., 2019. Fate of antibiotic resistant pseudomonas putida and broad host range plasmid in natural soil microcosms[J]. Frontiers in Microbiology, 10: 194.
DOI URL |
[19] |
FORSBERG K J, PATEL S, GIBSON M K, et al., 2014. Bacterial phylogeny structures soil resistomes across habitats[J]. Nature, 509(7502): 612-616.
DOI |
[20] |
GUO A Y, PAN C R, MA J Y, et al., 2020. Linkage of antibiotic resistance genes, associated bacteria communities and metabolites in the wheat rhizosphere from chlorpyrifos-contaminated soil[J]. Science of The Total Environment, 741(2): 140457.
DOI URL |
[21] |
HAN B H, MA L, YU Q L, et al., 2022. The source, fate and prospect of antibiotic resistance genes in soil: A review[J]. Frontiers In Microbiology, 13: 976657.
DOI URL |
[22] |
HAN X M, HU H W, CHEN Q L, et al., 2018. Antibiotic resistance genes and associated bacterial communities in agricultural soils amended with different sources of animal manures[J]. Soil Biology & Biochemistry, 126: 91-102.
DOI URL |
[23] |
HAO H, SHI D Y, YANG D, et al., 2019. Profiling of intracellular and extracellular antibiotic resistance genes in tap water[J]. Journal Of Hazardous Materials, 365: 340-345.
DOI PMID |
[24] |
HE L Y, LIU Y S, SU H C, et al., 2014. Dissemination of antibiotic resistance genes in representative broiler feedlots environments: Identification of indicator ARGs and correlations with environmental variables[J]. Environmental Science & Technology, 48(22): 13120-13129.
DOI URL |
[25] |
HE X L, XU Y B, CHEN J L, et al., 2017. Evolution of corresponding resistance genes in the water of fish tanks with multiple stresses of antibiotics and heavy metals[J]. Water Research, 124: 39-48.
DOI PMID |
[26] |
HEUER H, SCHMITT H, SMALLA K, 2011. Antibiotic resistance gene spread due to manure application on agricultural fields[J]. Current Opinion in Microbiology, 14(3): 236-243.
DOI PMID |
[27] |
HILL K E, TOP E M, 1998. Gene transfer in soil systems using microcosms[J]. FEMS Microbiology Ecology, 25(4): 319-329.
DOI URL |
[28] |
HOLMES A H, MOORE, L S P, SUNDSFJORD A, et al., 2016. Understanding the mechanisms and drivers of antimicrobial resistance[J]. Lancet, 387(10014): 176-187.
DOI PMID |
[29] |
HUANG X, LIU C X, LI K, et al., 2013. Occurrence and distribution of veterinary antibiotics and tetracycline resistance genes in farmland soils around swine feedlots in Fujian Province, China[J]. Environmental Science and Pollution Research, 20(12): 9066-9074.
DOI URL |
[30] |
HVISTENDAHL M, 2012. Public health. China takes aim at rampant antibiotic resistance[J]. Science, 336(6083): 795.
DOI PMID |
[31] |
HYDER S L, STREITFELD M M, 1978. Transfer of erythromycin resistance from clinically isolated lysogenic strains of streptococcus pyogenes via their endogenous phage[J]. Journal of Infectious Diseases, 138(3): 281-286.
PMID |
[32] | JI X L, SHEN Q H, LIU F, et al., 2012. Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China[J]. Journal of Hazardous Materials, 235-236: 178-185. |
[33] |
JOHNSTON C, MARTIN B, FICHANT G, et al., 2014. Bacterial transformation:distribution, shared mechanisms and divergent control[J]. Nature Reviews Microbiology, 12(3): 181-196.
DOI |
[34] |
KITTREDGE H A, DOUGHERTY K M, EVANS S E, 2022. Dead but not forgotten: How extracellular DNA, moisture, and space modulate the horizontal transfer of extracellular antibiotic resistance genes in soil[J]. Applied and Environmental Microbiology, 88(7): e0228021.
DOI URL |
[35] |
KORTRIGHT K E, CHAN B K, KOFF J L, et al., 2019. Phage therapy: A renewed approach to combat antibiotic-resistant bacteria[J]. Cell Host Microbe, 25(2): 219-232.
DOI PMID |
[36] |
LERMINIAUX N A, CAMERON A, 2019. Horizontal transfer of antibiotic resistance genes in clinical environments[J]. Canadian Journal of Microbiology, 65(1): 34-44.
DOI PMID |
[37] |
LI B, CHEN Z, ZHANG F, et al., 2020. Abundance, diversity and mobility potential of antibiotic resistance genes in pristine Tibetan Plateau soil as revealed by soil metagenomics[J]. FEMS Microbiology Ecology, 96(10): fiaa172.
DOI URL |
[38] |
LI T T, LI R C, CAO Y F, et al., 2022. Soil antibiotic abatement associates with the manipulation of soil microbiome via long-term fertilizer application[J]. Journal of hazardous materials, 439: 129704.
DOI URL |
[39] |
LI J J, XIN Z H, ZHANG Y Z, et al., 2017. Long-term manure application increased the levels of antibiotics and antibiotic resistance genes in a greenhouse soil[J]. Applied Soil Ecology, 121: 193-200.
DOI URL |
[40] |
LI H Z, ZHANG D D, YANG K, et al., 2020. Phenotypic tracking of antibiotic resistance spread via transformation from environment to clinic by reverse D2O single-cell raman probing[J]. Analytical Chemistry, 92(23): 15472-15479.
DOI URL |
[41] |
LIU J Y, GU J, WANG X J, et al., 2019. Evaluating the effects of coal gasification slag on the fate of antibiotic resistant genes and mobile genetic elements during anaerobic digestion of swine manure[J]. Bioresource Technology, 271: 24-29.
DOI PMID |
[42] | LIU M F, ZHANG L, HUANG L, et al., 2017. Use of natural transformation to establish an easy knockout method in riemerella anatipestifer[J]. Applied and Environmental Microbiology, 83(9): e00127-17. |
[43] |
LIU Z S, ZHAO Y X, ZHANG B F, et al., 2023. Deterministic effect of pH on shaping soil resistome revealed by metagenomic analysis[J]. Environmental science & technology. 57(2): 985-996.
DOI URL |
[44] |
LUBY E, IBEKWE A M, ZILLES J, et al., 2016. Molecular methods for assessment of antibiotic resistance in agricultural ecosystems: Prospects and challenges[J]. Journal of Environmental Quality, 45(2): 441-453.
DOI PMID |
[45] |
KHANNA M, STOTZKY M, 1992. Transformation of bacillus subtilis by DNA bound on montmorillonite and effect of DNase on the transforming Ability of Bound DNA[J]. Applied and Environmental Microbiology, 58(6): 1930-1939.
DOI PMID |
[46] |
MA Y, WILSON C A, NOVAK J T, et al., 2011. Effect of various sludge digestion conditions on sulfonamide, macrolide, and tetracycline resistance genes and class I integrons[J]. Environmental Science & Technology, 45(18): 7855-7861.
DOI URL |
[47] |
MARTI R, TIEN Y C, MURRAY R, et al., 2014. Safely coupling livestock and crop production systems: how rapidly do antibiotic resistance genes dissipate in soil following a commercial application of swine or dairy manure?[J]. Applied and Environmental Microbiology, 80(10): 3258-3265.
DOI PMID |
[48] |
MARTÍNEZ J L, 2008. Antibiotics and antibiotic resistance genes in natural environments[J]. Science, 321(5887): 365-367.
DOI PMID |
[49] |
MATTHIESSEN L, BERGSTROM R, DUSTDAR S, et al., 2016. Increased momentum in antimicrobial resistance research[J]. Lancet, 388(10047): 865.
DOI PMID |
[50] |
MANZONI S, SCHIMEL J P, PORPORATO A, 2012. Responses of soil microbial communities to water stress: Results from a meta-analysis[J]. Ecology, 93(4): 930-938.
DOI PMID |
[51] |
MAO D Q, LUO Y, MATHIEU J, WANG Q, et al., 2014. Persistence of extracellular DNA in river sediment facilitates antibiotic resistance gene propagation[J]. Environmental Science &Technology, 48(1): 71-78.
DOI URL |
[52] |
MACEDO G, OLESEN A K, MACCARIO L et al., 2022. Horizontal gene transfer of an IncP1 plasmid to soil bacterial community introduced by Escherichia coli through manure amendment in soil microcosms[J]. Environmental Science & Technology, 56(16): 11398-11408.
DOI URL |
[53] |
MUNIR M, XAGORARAKI I, 2011. Levels of antibiotic resistance genes in manure, biosolids, and fertilized soil[J]. Journal Of Environmental Quality, 40(1): 248-255.
PMID |
[54] |
MUSOVIC S, DECHESNE A, SORENSEN J, et al., 2010. Novel assay to assess permissiveness of a soil microbial community toward receipt of mobile genetic elements[J]. Applied and Environmental Microbiology, 76(14): 4813-4818.
DOI PMID |
[55] |
MUURINEN J, STEDTFELD R, KARKMAN A, et al., 2017. Influence of manure application on the environmental resistome under finnish agricultural practice with restricted antibiotic use[J]. Environmental Science & Technology, 51(11): 5989-5999.
DOI URL |
[56] |
NEGREANU Y, PASTERNAK Z, JURKEVITCH E, 2012. Impact of treated wastewater irrigation on antibiotic resistance in agricultural soils[J]. Environmental science & technology, 46(9): 4800-4808.
DOI URL |
[57] |
PAN M, CHU L M, 2018. Occurrence of antibiotics and antibiotic resistance genes in soils from wastewater irrigation areas in the Pearl River Delta region, southern China[J]. Science of The Total Environment, 624: 145-152.
DOI URL |
[58] |
PENG S, FENG Y Z, WANG Y M, et al., 2017. Prevalence of antibiotic resistance genes in soils after continually applied with different manure for 30 years[J]. Journal of Hazardous Materials, 340: 16-25.
DOI PMID |
[59] |
QIAN X, GU J, SUN W, et al., 2018. Diversity, abundance, and persistence of antibiotic resistance genes in various types of animal manure following industrial composting[J]. Journal Of Hazardous Materials, 344: 716-722.
DOI PMID |
[60] | QIAN X, GUNTURU S, GUO J R, et al., 2020. Metagenomic analysis reveals the shared and distinct features of the soil resistome across tundra, temperate prairie and tropical ecosystems[J]. Microbiome 9(1): 6530. |
[61] |
QIAN X, SUN W, GU J, et al., 2016. Reducing antibiotic resistance genes, integrons, and pathogens in dairy manure by continuous thermophilic composting[J]. Bioresource Technology, 220: 425-432.
DOI PMID |
[62] |
RAYNER C, MUNCKHOF W J, 2005. Antibiotics currently used in the treatment of infections caused by Staphylococcus aureus[J]. Internal Medicine Journal, 35(Suppl 2): 3-16.
DOI URL |
[63] |
RIBER L, POULSEN P H, AL-SOUD W A, et al., 2014. Exploring the immediate and long-term impact on bacterial communities in soil amended with animal and urban organic waste fertilizers using pyrosequencing and screening for horizontal transfer of antibiotic resistance[J]. FEMS Microbiol Ecol, 90(1): 206-224.
DOI PMID |
[64] |
ROSS J, TOPP E, 2015. Abundance of antibiotic resistance genes in bacteriophage following soil fertilization with dairy manure or municipal biosolids, and evidence for potential transduction[J]. Applied and Environmental Microbiology, 81(22): 7905-7913.
DOI PMID |
[65] | SAEKI K, KUNITO T, SAKAI M, 2010. Effects of pH, ionic strength, and solutes on DNA adsorption by andosols[J]. Biology & Fertility of Soils, 46(5): 531-535. |
[66] | SCALLAN E, HOEKSTRA R M, MAHON B E, et al., 2015. An assessment of the human health impact of seven leading foodborne pathogens in the United States using disability adjusted life years[J]. Epidemiology & Infection, 143(13): 2795-2804. |
[67] |
SHUANG P, FENG Y Z, WANG Y M, et al., 2017. Prevalence of antibiotic resistance genes in soils after continually applied with different manure for 30 years[J]. Journal of Hazardous Materials, 340: 16-25.
DOI PMID |
[68] | SHEN C, ZHONG L L, YANG Y, et al., 2020. Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing-based molecular epidemiological study[J]. The Lancet Microbe, 1(1): 34-43. |
[69] |
LEE G H, STOZKY G, 1999. Transformation and survival of donor, recipient, and transformants of Bacillus subtilis in vitro and in soil[J]. Soil Biology and Biochemistry, 31(11): 1499-1508.
DOI URL |
[70] |
SCHMIEGER H, SCHICKLMAIER P, 1999. Transduction of multiple drug resistance of Salmonella enterica serovar typhimurium DT104[J]. FEMS Microbiology Letters, 1999, 170(1): 251-256.
PMID |
[71] |
SIROIS S H, BUCKLEY D H, 2019. Factors governing extracellular DNA degradation dynamics in soil[J]. Environmental Microbiology Reports, 11(2): 173-184.
DOI PMID |
[72] |
SKOLD O, 2000. Sulfonamide resistance: Mechanisms and trends[J]. Drug resistance updates. 3(3): 155-160.
DOI URL |
[73] |
SUN J T, JIN L, HE T T, et al., 2020. Antibiotic resistance genes (ARGs) in agricultural soils from the Yangtze River Delta, China[J]. Science of The Total Environment, 740: 140001.
DOI URL |
[74] |
SUN M M, YE M, JIAO W T, et al., 2018. Changes in tetracycline partitioning and bacteria/phage-comediated ARGs in microplastic-contaminated greenhouse soil facilitated by sophorolipid[J]. Journal Of Hazardous Materials, 345: 131-139.
DOI PMID |
[75] |
SUN M M, YE M, ZHANG Z Y, et al., 2019. Biochar combined with polyvalent phage therapy to mitigate antibiotic resistance pathogenic bacteria vertical transfer risk in an undisturbed soil column system[J]. Journal Of Hazardous Materials, 365: 1-8.
DOI PMID |
[76] | SU H C, LIU Y S, PAN C G, et al., 2017. Persistence of antibiotic resistance genes and bacterial community changes in drinking water treatment system: From drinking water source to tap water[J]. Science of the Total Environment, 616-617: 453-461. |
[77] |
TANG X J, LOU C L, WANG S X, et al., 2015. Effects of long-term manure applications on the occurrence of antibiotics and antibiotic resistance genes (ARGs) in paddy soils: Evidence from four field experiments in south of China[J]. Soil Biology and Biochemistry, 90: 179-187.
DOI URL |
[78] | UDIKOVIC-KOLIC N, WICHMANN F, BRODERICK N A, et al., 2014. Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization[J]. Proceedings of the National Academy of Sciences of the United States of America, 111(42): 15202-15207. |
[79] |
WANG F H, QIAO M, SU J Q, et al., 2014. High throughput profiling of antibiotic resistance genes in urban park soils with reclaimed water irrigation[J]. Environmental Science & Technology, 48(16): 9079-9085.
DOI URL |
[80] |
WANG F H, QIAO M, CHEN Z, et al., 2015. Antibiotic resistance genes in manure-amended soil and vegetables at harvest[J]. Journal of Hazardous Materials, 299: 215-221.
DOI URL |
[81] |
WU N, QIAO M, ZHANG B, et al., 2010. Abundance and diversity of tetracycline resistance genes in soils adjacent to representative swine feedlots in China[J]. Environmental Science & Technology, 44(18): 6933-6939.
DOI URL |
[82] |
WU Y, CUI E P, ZUO Y R, et al., 2018. Fate of antibiotic and metal resistance genes during two-phase anaerobic digestion of residue sludge revealed by metagenomic approach[J]. Environmental Science and Pollution Research, 25(14): 13956-13963.
DOI |
[83] |
XU H, CHEN Z Y, HUANG R Y, et al., 2021. Antibiotic resistance gene-carrying plasmid spreads into the plant endophytic bacteria using soil bacteria as carriers[J]. Environmental Science & Technology, 55(15): 10462-10470.
DOI URL |
[84] |
XIAO K Q, LI B, MA L P, et al., 2016. Metagenomic profiles of antibiotic resistance genes in paddy soils from South China[J]. FEMS Microbiology Ecology, 92(3): fiw023.
DOI URL |
[85] |
XIE W Y, MCGRATH S P, SU J Q, et al., 2016. Long-term impact of field applications of sewage sludge on soil antibiotic resistome[J]. Environmental Science & Technology, 50(23): 12602-12611.
DOI URL |
[86] |
YANG Y Y, LIU G H, YE C, et al., 2019. Bacterial community and climate change implication affected the diversity and abundance of antibiotic resistance genes in wetlands on the Qinghai-Tibetan Plateau[J]. Journal of Hazardous Materials, 361: 283-293.
DOI PMID |
[87] |
YUAN K, WANG X W, CHEN X, et al., 2019a. Occurrence of antibiotic resistance genes in extracellular and intracellular DNA from sediments collected from two types of aquaculture farms[J]. Chemosphere, 234: 520-527.
DOI URL |
[88] |
YUAN Q B, YU P F, CHENG Y, et al., 2022. Chlorination (but not UV disinfection) generates cell debris that increases extracellular antibiotic resistance gene transfer via proximal adsorption to recipients and upregulated transformation genes[J]. Environmental Science & Technology, 56(23): 17166-17176.
DOI URL |
[89] |
YUAN Q B, HUANG Y M, WU W B, et al., 2019b. Redistribution of intracellular and extracellular free & adsorbed antibiotic resistance genes through a wastewater treatment plant by an enhanced extracellular DNA extraction method with magnetic beads[J]. Environment International, 131: 104986.
DOI URL |
[90] | ZAREI-BAYGI A, SMITH A L, 2021. Intracellular versus extracellular antibiotic resistance genes in the environment: Prevalence, horizontal transfer, and mitigation strategies[J]. Environment International, 319: 124181. |
[91] |
ZHANG H C, CHANG F Y, SHI P, et al., 2019b. Antibiotic resistome alteration by different disinfection strategies in a full-scale drinking water treatment plant deciphered by metagenomic assembly[J]. Environmental Science & Technology, 53(4): 2141-2150.
DOI URL |
[92] |
ZHANG J Y, SUI Q W, TONG J, et al., 2018b. Soil types influence the fate of antibiotic-resistant bacteria and antibiotic resistance genes following the land application of sludge composts[J]. Environment International, 118: 34-43.
DOI URL |
[93] |
ZHANG Q Q, YING G G, PAN C G, et al., 2015. Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance[J]. Environmental Science & Technology, 49(11): 6772-6782.
DOI URL |
[94] |
ZHANG Y T, HAO X Y, THOMAS B W, et al., 2023. Soil antibiotic resistance genes accumulate at different rates over four decades of manure application[J]. Journal Of Hazardous Materials, 443(Part B): 130136.
DOI URL |
[95] |
ZHANG Y, LI A L, DAI T J, et al., 2018a. Cell-free DNA: A neglected source for antibiotic resistance genes spreading from WWTPs[J]. Environmental Science & Technology, 52(1): 248-257.
DOI URL |
[96] |
ZHANG Y J, HU H W, CHEN Q L, et al., 2019a. Transfer of antibiotic resistance from manure-amended soils to vegetable microbiomes[J]. Environment International, 130: 104912.
DOI URL |
[97] |
ZHANG Y P, SNOW D D, PARKER D, et al., 2013. Intracellular and extracellular antimicrobial resistance genes in the sludge of livestock waste management structures[J]. Environmental Science & Technology, 47(18): 10206-10213.
DOI URL |
[98] |
ZHAO X, WANG J H, ZHU L S, et al., 2019. Field-based evidence for enrichment of antibiotic resistance genes and mobile genetic elements in manure-amended vegetable soils[J]. Science of The Total Environment, 654: 906-913.
DOI URL |
[99] |
ZHENG D S, YIN G Y, LIU M, et al., 2022. Global biogeography and projection of soil antibiotic resistance genes[J]. Science Advances, 8(46): eabq8015.
DOI URL |
[100] |
ZHOU X, QIAO M, SU J Q, et al., 2019. Turning pig manure into biochar can effectively mitigate antibiotic resistance genes as organic fertilizer[J]. Science of The Total Environment, 649: 902-908.
DOI URL |
[101] | ZHOU Y T, NIU L L, ZHU S Y, et al., 2017. Occurrence, abundance, and distribution of sulfonamide and tetracycline resistance genes in agricultural soils across China[J]. Science of The Total Environment, 599-600: 1977-1983. |
[102] |
ZHU D, XIANG Q, YANG X R, et al., 2019. Trophic transfer of antibiotic resistance genes in a soil detritus food chain[J]. Environmental Science & Technology, 53(13): 7770-7781.
DOI URL |
[103] | ZHU Y G, JOHNSON T A, SU J Q, et al., 2013. Diverse and abundant antibiotic resistance genes in Chinese swine farms[J]. Proceedings of the National Academy of Sciences of the United States of America, 110(9): 3435-3440. |
[104] |
冀秀玲, 刘芳, 沈群辉, 等, 2011. 养殖场废水中磺胺类和四环素抗生素及其抗性基因的定量检测[J]. 生态环境学报, 20(5): 927-933.
DOI |
JI X L, LIU F, SHEN Q H, et al., 2011. Quantitative detection of sulfonamides and tetracycline antibiotics and resistance genes in sewage farms[J]. Ecology and Environmental Sciences, 20(5): 927-933. | |
[105] |
胡雪莹, 张越, 郭雅杰, 等, 2022. 不同施肥处理农田土壤中噬菌体与细菌携带抗生素抗性基因的比较[J]. 生物技术通报, 38(9): 116-126.
DOI |
HU X Y, ZHANG Y, GUO Y J, et al., 2022. Comparison in antibiotic resistance genes carried by bacteriophages and bacteria in farmland soil amended with different fertilizers[J]. Biotechnology Bulletin, 38(9): 116-126. | |
[106] | 王娜, 郭欣妍, 单正军, 等, 2021. 农田土壤抗生素污染管控建议[J]. 中国工程科学, 23(1): 167-173. |
WANG N, GUO X Y, SHAN Z J, et al., 2021. Suggestions for management and control of antibiotics in farmland soil in China[J]. Chinese Journal of Engineering Science, 23(1): 167-173. |
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